Biological applications of ionophores
WebIonophores are compounds that form lipid soluble, dynamically reversible complexes with cations and by this means facilitate specific ionic transport across biologic membranes (Pressman, 1976; Reed, 1982; Taylor et al., 1982 ). There are two major subclasses of ionophores, (1) neutral ionophores, which are highly toxic because they form charged ... WebNov 1, 2024 · Copper ionophores alter the concentration, distribution, and reactivity of endogenous copper ions with consequent profound biological repercussions. The …
Biological applications of ionophores
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WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been … WebIonophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design.
WebBiological applications of ionophores. by B C Pressman. Annual review of biochemistry. Read more related scholarly scientific articles and abstracts. WebMar 1, 2024 · Herein, the biological applications of Zn ionophores are reviewed, discussing the coordination chemistry, the mechanism of action, and interactions with target …
WebMar 4, 2024 · The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer ... WebIonophores are a class of compounds that form complexes with specific ions and facilitate their transport across cell membranes. An ionophore typically has a hydrophilic pocket (or hole) that forms a binding site specific for a particular ion. The exterior surface of an ionophore is hydrophobic, allowing the complexed ion in its pocket to cross the …
WebOct 9, 2016 · Biological applications of ionophores. Annu Rev Biochem. 1976; 45:501–530. [Google Scholar] Reiner R, Weiss U, Brombacher U, Lanz P, Montavon M, Furlenmeier A, Angehrn P, Probst PJ. Ro 13-9904/001, a novel potent and long-acting parenteral cephalosporin. J ...
WebMar 15, 2024 · As such, an essential part of all applications is a letter of sponsorship from the BSD faculty member with whom the applicant proposes to work, outlining the … crypto regulation in singaporeWebNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to … crypto regulatory complianceWebMar 4, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo- 5-chloro-8-hydroxyquinoline (CQ) that was first used as an antibiotic and more recently has been studied for the repurposing in different diseases ranging from neurodegenerative … crypto regulation in the ukWebAug 13, 2024 · Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and … crypto regulation meetingWebFeb 15, 2015 · 6 Structure and Biological Activity of Polyether Ionophores and Their. ... Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of ... crypto regulations 2023WebAbstract. Ionophores are substances which facilitate the movement of ions into and/or through organic phases. The two major classes of compounds are the neutral ionophores, which form charged clathrate complexes with ions, and the carboxylic polyether ionophores which are neutral in the complexed state. Many of the ionophores exclusively bind ... crypto reitWebPressman BC (1976) Biological applications of ionophores. Ann Rev Biochem 45:501–530. CrossRef PubMed CAS Google Scholar Puskin JS, Gunter TE (1975) Electron paramagnetic resonance of copper ion and manganese ion complexes with the ionophore A23187. Biochemistry 14:187–191 . CrossRef ... crypto regulation in us