Circrhobtb3
WebCircRHOBTB3 was downregulated in ovarian cancer tissues and cells. RESULTS: Functionally, circRHOBTB3 overexpression could markedly suppress cell proliferation, metastasis and glycolysis, whereas the opposite results could be observed in the deletion of circRHOBTB3. Additionally, xenograft experiment also identified the above results. WebNational Center for Biotechnology Information
Circrhobtb3
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WebMechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to ... WebApr 13, 2024 · Background Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA development. However, the intrinsic mechanism of chondrocyte senescence is still unclear. This study aimed to investigate …
WebAmong them, 6 circRNAs (circBNC2, circEXOC6B, circFAM13B, circN4BP2L2, circRHOBTB3 and circCELSR1) have been associated with various clinicopathological features of epithelial ovarian cancer (EOC). More importantly, circEXOC6B and circN4BP2L2 may act as novel diagnostic biomarkers in patients with EOC . Another … WebFeb 11, 2024 · Conclusions circRHOBTB3 plays a tumor-suppressive role in CRC and has to be excreted out of cells to sustain cancer cell fitness. ASOs targeting regulatory elements for circularization and...
WebMar 20, 2024 · CircRHOBTB3 expression is upregulated in CC cells, and circRHOBTB3 knockdown repressed CC cell proliferation, migration, and invasion. Furthermore, …
WebArticle Title: The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Journal: Journal of Ovarian Research doi: 10.1186/s13048-022-00979-1 Figure Legend Snippet: CircRHOBTB3 is down-regulated in EOC.
WebJun 2, 2024 · The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Rising evidences bespeak that circular RNAs are indispensable in regulating cellular biological behaviors and engaging in diseases' occurrence. csl olympia waWebMar 20, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4. eagle rock hicksville reviewsWebFigure Legend Snippet: circRHOBTB3 promotes PANC-1 cell proliferation by activating autophagy response. a The protein level of p62 and LC3B were determined by western blotting in PANC-1 cells transfected circRHOBTB3 overexpressing vector with or without 3-Methyladenine (3-MA, 2.5 mM, 24 h) treatment. b The mCherry-GFP-LC3B labeled … csl one2freeWebJun 1, 2024 · CircRHOBTB3 has been reported to participate intimately in the progression of some cancers. Nevertheless, the mechanism by which circRHOBTB3 regulates … eagle rock heating and airWebFor instance, EIF4A3 can induce the expression of circMMP9 and circASAP1, 51, 52 FUS can induce abnormally high expression of circRHOBTB3 and circ_002136 in tumors. 53, 54 Through analysis of the Circular RNA Interactome online database, 55 we found that EIF4A3 and FUS contain binding sites eagle rock hazleton pa new years eveWebcircRHOBTB3是通过宿主基因RHOBTB3的剪接和环化产生的。 作为Rho GTPase家族的ATPase，宿主基因RHOBTB3参与膜转运和蛋白酶体降解，可通过促进肾癌中HIF-α的蛋白酶体降解来抑制肿瘤生长。 先前的研究还表明circRHOBTB3在卵巢癌、胃癌、CRC和肝细胞癌（HCC）中是一种肿瘤抑制性circRNA。 然而，其环化模式和外泌体分泌途径尚不明 … eagle rock high footballWebJun 1, 2024 · circRHOBTB3 regulated PTEN/Akt pathway by serving as the ceRNA of miR-23a-3p. Moreover, it has been widely recognized, as a tumor-suppressive gene, PTEN … csl ohio