WebMotivation: To fully understand how a protein kinase regulates biological processes, it is imperative to first identify its substrate(s) and interacting protein(s). However, of the 518 known human serine/threonine/tyrosine kinases, 35% of these have ... WebPhosphoPOINT has integrated three existing phospho-protein databases, including Phospho.ELM, HPRD, SwissProt, and our manually curated 400 kinase–substrate pairs. …
PhosphoPOINT: a comprehensive human kinase …
WebJun 23, 2016 · To generate a large source of experimentally derived KSRs, we combined the knowledge of four resources: PhosphoSitePlus , PhosphoELM , PhosphoPOINT and Human Protein Reference Database (HPRD) . Overall this integrated database contained 396 kinases, 76% coverage of the human kinome . There were approximately 8,000 … WebTo use PhosphoPOINT data, a human orthologue for the gene identified was searched. The assignment of orthology was taken from a recent meta-analysis28and review29; orthologies used are in Data S1 for phosphatases and in Lehmann et al.20for kinases. PhosphoPOINT data for the human orthologues were then converted back to the C. elegans orthologues. philips carina
Polyphosphate - Wikipedia
WebPolyphosphates are salts or esters of polymeric oxyanions formed from tetrahedral PO 4 structural units linked together by sharing oxygen atoms.Polyphosphates can adopt linear … WebAug 9, 2008 · PhosphoPOINT annotates the interactions among kinases, with their down-stream substrates and with interacting (phospho)-proteins to modulate the … WebDec 23, 2014 · By extracting information from PhosphoPOINT, the human interactome and phosphoprotein database, we further generated protein networks that permit the identification of two key kinases as regulators of tumor cell growth that control cell growth, the FER and CRKL tyrosine kinases that form a pivotal subnetwork which controls the … truth 7 crossword