WebbLu-177 DOTA-TATE or Lu-177 DOTA-TOC was administered to the patients by slow intravenous infusion over 10–15 min. For renal protection, all patients received 1500 mL of an amino acid infusion (250 mL NaCl plus Lysine HCL 5% plus 250 mL L-Arginine HCL 10%) over 4 h. In 34 patients a total of 101 PRRT cycles were performed. WebbLu-177-DOTA-TATE; PRRT; everolimus; mTOR inhibitor; neuroendocrine tumors 1. Introduction Neuroendocrine tumors (NETs) represent a rare entity of neoplasms with increasing incidence over the last years and high heterogeneity with respect to the primary tumor site, tumor grading, and pathophysiological properties such as hormonal activity.
memo inOncology / memo inHaematology on LinkedIn: Phase II …
Webb17 maj 2024 · Rationale: Peptide receptor radionuclide therapy (PRRT) with 177 Lu-DOTATATE (oxodotreotide) results in external radiation exposure from the patient. In the … WebbLutetium (177 Lu) oxodotreotide or 177 Lu DOTA-TATE, trade name Lutathera, is a chelated complex of a radioisotope of the element lutetium with DOTA-TATE, used in peptide receptor radionuclide therapy (PRRT).Specifically, it is used in the treatment of cancers which express somatostatin receptors.. Alternatives to 177 Lu-DOTATE include … bio austin butler
FDA approves lutetium Lu 177 dotatate for treatment of GEP-NETS
WebbFor patients with inoperable or metastatic NETs, 177 Lu-DOTATATE is an effective treatment with minimal side effects. The efficacy of 177 Lu-DOTATATE peptide … Webbsomatostatin (SST) analogs, peptide receptor radionuclide therapy (PRRT) offers therapeutic strategy, as the majority of GEP tumors possess somatostatin receptors (SSTRs). Somatostatin analogs featuring a DOTA-chelator can be radiolabeled with the β-emitters radioisotopes, Yttrium-90 (90Y) and Lutetium-177 (177Lu) for PRRT. Webb1 mars 2024 · In recent years, promising results for peptide receptor radionuclide therapy (PRRT) with either 177 Lu- or 90 Y-labeled compounds in salvage meningioma have been reported, and its potential was recently recognized in the European Association of Neuro-Oncology guidelines on meningioma ( 3 ). bioauxilium research