WebJan 1, 1995 · Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids. The Journal of Organic Chemistry 1998 , 63 (15) , 5137-5143. WebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage.
Aberrant expression of mucin core proteins and o-linked glycans ...
WebApr 15, 2006 · CLA defines a subset of human peripheral helper memory T cells and has long been used as a specific carbohydrate determinant in characterizing skin-homing helper memory T-cell populations. 5 The HECA-452 antibody defining CLA was shown to recognize the sialyl Lewis X (Le x) determinant, which is known as a typical carbohydrate ligand for ... WebAug 15, 1995 · After removal of sialic acids, most of the mucins rich in sialyl-Lewis(a) and sialyl-Lewis(x) oligosaccharides no longer bound to a DEAE-cellulose column at pH 8.0. These results indicate that at least part of the sialyl-Lewis(a) and sialyl-Lewis(x) in SW1990 cells is associated with the MUC1 polypeptide. dictionary\\u0027s 13
Ultrasmall superparamagnetic nanoparticles targeting E-selectin ...
WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the … WebWe investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease. WebJan 22, 2015 · Cell adhesion via selectins also results in signaling that may contribute to integrin activation and the transition of rolling cells to firm arrest. 3,4 The sialofucosylated glycans that bind all 3 selectins include the tetrasaccharide sialyl Lewis-X (sLe X) and related structures. 5,6 Although many cell-surface glycoconjugates express such ... citydoc moorgate address